The article below will focus on description of the symptoms of alcohol withdrawal, the researcher’s use of genetic animal models of alcohol withdrawal to induce physical dependence (Inbred Strains, Selective Breeding), and the involvement of neurotransmitters, receptors, and ion channels in the syndrome (GABA-A Receptor Complex, Steroidal GABA Agonists, NMDA Receptor Complex, Voltage-Sensitive Calcium Channels).