An original article published in May-June 2007 described to enhance wound closure in acute full-thickness dermal wounds in healthy individuals. With Autologous Platelet Gel (APG) the wound closure velocity was greater than that 
of control wounds, according to the article which is one of JAMA/Archive Journals.
Nowadays, APG is broadly used in reconstructive, cosmetic, orthopedic, cardiovascular, oral maxillofacial, and dermatologic surgery in an attempt to improve tissue healing. But it remained controversial when received mixed reviews in clinical reports as its use to reduce ecchymosis and edema.
As to compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers, the study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh, and an antibiotic ointment and/or a semiocclusive dressing was applied on the other thigh. Healing was monitored for spontaneous wound closure by clinical assessment and by digital photographs over 6 months. Over 35 days, 64 serial dermal biopsy specimens (6 mm diameter) were analyzed (using hematoxylin-eosin, Mason trichrome, CD-34, and Ki-67 stains) to measure differences between treated and control sites for cellularity, granulation formation, vascularity, epithelialization, and cellular replication.
David B. Hom, MD; Bradley M. Linzie, MD; Trevor C. Huang, PhD in their pilot study provides preliminary evidence that topical APG may hasten wound closure in full-thickness dermal wounds in healthy individuals.
By increasing our understanding of APG on acute full-thickness skin wounds, new growth factor interventions may improve soft tissue healing in surgical patients. If APG treatment accelerates acute dermal healing, it could prevent and reduce some postsurgical wound healing complications commonly seen in patients who are susceptible to poor healing.
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