Major mechanisms causing brain damage in stroke are described in the following article of Neurology. It covers materials such as Focal Ischemic Injury, Cerebral Blood Flow, Mechanisms of Neuronal Injury, Ischemic Penumbra, Neuronal Death, Ischemic Stroke, Thrombosis, Embolism, Global-Ischemic or Hypotensive Stroke, and Question and Answers in association with Pathophysiology of Stroke.