The Journal covers clinical therapeutics of Sickle Cell Anemia regarding hydroxyurea’ treatment sections such the Clinical Problem, Pathophysiology and Effect of Therapy (click picture to enlarge), Clinical evidence, Hydroxyurea Clinical Use, Adverse Effects of Hydroxyurea, Peripheral-Blood Thresholds for Adjustment of the Dose of Hydroxyurea, and Areas of Uncertainty in the Hydroxyurea treatment.