Nephrotic syndrome is a collection of symptoms which occur because the tiny blood vessels (the glomeruli) in the kidney become leaky. This allows protein (normally never passed out in the urine) to leave the body in large amounts   (medical-dictionary).  Nephrotic syndrome is a nonspecific disorder in which the kidneys are damaged, causing them to leak large amounts of protein (proteinuria) at least 3.5 grams per day per 1.73m2 body surface area) from the blood into the urine (wikipedia.org)

In this article we can find Pathophysiology, Epidemiology, Classification, Steroid-sensitif Nephrotic Syndrome, Steroid-resistant Nephrotic Syndrome, Complications of Nephrotic Syndrome, and Ancillary Therapy of Nephrotic Syndrome. After read this, the readers should be able to explain the mechanism and the consequences of proteinuria, make a presumptive diagnosis of minimal-change nephrotic syndrome, interpret the signs associated with steroid resistance, ascertain the timing and the indications for a kidney biopsy, gauge the indications for referral to a pediatric, nephrologist, determine the adequacy of the therapy, and predict the disease course.

The original article was written by Roberto Gordillo, MD and Adrian Spitzer from Albert Einstein College of Medicine/Children’s Hospital at Montefiore, Division of Pediatric Nephrology, Bronx, NY in American Academy of Pediatric, March 2009 issue.

Nephrotic syndrome encompasses a diverse group of conditions that share the common denominator of massive loss of protein in the urine. Progress in identifying the cause and pathogenesis of each of these conditions has been slow. The current identification of various forms of nephrotic syndrome is based primarily on histologic findings, which are not always pathognomonic. Treatment has and still depends on drugs that lack specificity and have numerous, often serious, adverse effects.

Find completely about The Nephrotic Syndrome and its associated aspects in Pediatrics Reviewed Journal here. Fourteen pages of PDF filetype (source:pedsinreview.aappublications.org, medical-dictionary.thefreedictionary.com).