Currently, there is an option for patients with metastatic Renal Cell Carcinoma (RCC), Dendritic Cell (DC)-based vaccines are currently under active clinical investigation. DCs, play an important role in the induction of CD8+ and CD4+ T-cell responses in vivo, therefore, vaccination with antigen-loaded DCs has developed into an attractive approach to induce cellular, potentially therapeutic, immune responses in cancer patients. This was described in the American Association for Cancer Research Journal.

As stated, autologous dendritic cells transfected with total renal tumor RNA have been shown to be potent stimulators antitumor immunity in vitro. The researcher then tried to induce tumor-specific T-cell responses in subjects with metastatic renal cell carcinoma and evaluated the feasibility, safety, and its efficacy.

This report of research was written by Zhen Su, Jens Dannull, Axel Heiser, Donna Yancey, Scott Pruitt, John Madden, Doris Coleman, Donna Niedzwiecki, Eli Gilboa and Johannes Vieweg from Duke University Medical Center, Durham, North Carolina. They administered Renal tumor RNA-transfected dendritic cells to 10 patients with no evidence of dose-limiting toxicity or vaccine-related adverse effects including autoimmunity.

They showed that the administration of RCC RNA-transfected DCs is not only safe and feasible but also capable of stimulating the expansion of tumor-specific, polyclonal T cells in the immunized patients,

Our data provide evidence on vaccine safety and in vivo bioactivity of RNA-loaded DCs in patients with metastatic RCC, although the proof for clinical benefit remains to be established in future clinical trials. This study establishes the foundation for additional optimization and refinements of the RNA-loaded DC strategy with the ultimate goal of developing therapeutic vaccines for cancer patients.

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