The following article describes you with an algorithm of high-dose propofol infusion in head injury or intracranial 
hypertension. Propofol (Diprivan) is a short-acting, intravenous, nonbarbiturate sedative agent used for the induction of general anesthesia for adults and children, maintenance of general anesthesia, sedation in various medical contexts such as intubated, ventilated adults, colonoscopy, endoscopy and etc (source: wikipedia.org).
Several recent reports recorded a severe or fatal syndrome associated with a high-dose propofol infusion which is showed by metabolic acidosis, rhabdomyolysis and refractory arrhytmias. Commonly, propofol is used in ICU for sedation purposes in doses up to 50 mcg/kg/minute. A larger doses greater than 83 mcg/kg/minute more than 24 hours will perform a propofol infusion syndrome, according to the article. Please follow the algorithm diagram within for a clear and brief descriptions.
Within the article, you will also be given with explanation about propofol recommendation levels and literatures review that describe propofol was as effective as morphine in controlling intracranial hypertension, propofol-induced bradycardia, cardiac arrests in head-injured patients receiving propofol.
The article stated that this so-called guideline which is issued by the Department of Surgical Education, Orlando Regional Medical Center is intended to serve as a general statement regarding appropriate patient care practice and should not be accepted as a protocol or policy nor replace clinical judgment of individual patients.
Complete read High-Dose Propofol Infusion Algorithm for Intracranial Hypertension here in pdf filetype medical prescription article (source: surgicalcriticalcare.net).
