Systemic Lupus Erythematosus (SLE) is a kind of immunological by mediated disease consisting of multiple organs 
involvement. Thus, SLE can affect every organ in the body. Below we provide information about the Diagnostic Criteria of SLE which are issued by the American College of Rheumatology (ACR).
These SLE diagnostic criteria combine clinical signs and symptoms with abnormalities detected in blood tests such as positive ANA test (anti-nuclear antibody), thrombocytopaenia, and reflect the role of antiphospolipid antibodies of SLE patients. The diagnosis of SLE is often difficult since the symptoms are similar to other diseases, but the most common signs of lupus are joint pain, swollen joint, moderate fatique to severe, skin rashes, chest pain, sensitivity to light, rash on the cheek and nose (shape a butterfly rash), Raynaud’s syndrome, and anemia.
Then, a diagnosis of an SLE can be made if a person has 4 of the following 11 criteria simultaneously or in succession. This criteria known as the American College of Rheumatology (ACR) which consist of 11 criteria or symptoms that are used to diagnose SLE. We provide you the Diagnostic Criteria of Systemic Lupus Erythematosus in the following table :
| Criterion | Description |
| 1. Malar Rash | Fixed erythema over the malar eminences, tending to spare the nasolabial folds |
| 2. Discoid Rash | Erythematosus raised patches, may scar |
| 3. Photosensitivity | Skin rash as a result of unusual reaction to sunlight |
| 4. Oral ulcers | Usually painless |
| 5. Arthritis | Non-erosive: Jaccoud’s arthropathy |
| 6. Serositis | a. Pleuritis (pleuritic pain, pleural rub, pleural effusion) b. Pericarditis (ECG changes, rub, pericardial effusion) |
| 7. Renal Disorder | a. Proteinuria (>3+ or 0.5 g/day) b. Cellular casts in urine |
| 8.Neurological Disorder | a. Seizures b. Psychosis |
| 9. Haematolological Disorder | a. Haemolytic Anemia b. Leukopaenia c. Lymphopaenia d. Thrombosytopaenia |
| 10. Immunological Disorder | a. Anti-DNA antibodies b. Anti-Sm antibodies c. Anti-phospolipid antibodies |
| 11. Anti-nuclear antibody | Exclude drug causes |
