This anemia articles base from data suggest that high-level folic acid fortification delays the diagnosis of or exacerbates the effects of vitamin B-12 deficiency, according to the background of this article. After examined the relations between serum folate and vitamin B-12 status relative to anemia, macrocytosis, and cognitive impairment the researchers conclude that low vitamin B-12 status, high serum folate was associated with anemia and cognitive impairment. When vitamin B-12 status was normal, however, high serum folate was associated with protection against cognitive impairment.

Martha Savaria Morris and colleagues from Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, studied direct associations between high serum folate and both anemia and cognitive impairment in subjects with low vitamin B-12 status. Among subjects with normal vitamin B-12 status, on the other hand, high serum folate was associated with protection from cognitive impairment.

They claimed that their finding are the most consistent in case reviews of folic acid precipitates both hematologic and neuropsychiatric manifestations of vitamin B-12 deficiency.

In full read article, we can find Subject and Methods which consist of Study population, Assessment of anemia and macrocytosis, Assessment of cognitive function, Biochemical measurements, Classification of subjects according to vitamin B-12 and folate status, and Statistical analyses. In its result chapter, it consist of Subject description: characteristics and study outcomes, Subject characteristics in relation to anemia, macrocytosis, and cognitive impairment, Vitamin B-12 status in relation to subject characteristics and study outcomes, Interaction between vitamin B-12 status and serum folate in relation to anemia and cognition,and Association between serum vitamin B-12 and serum folate.

Find Full Article about Anemia relationships with Folate and vitamin B-12 status – Reviewed Anemia Journal here, full 15 pages in PDF format (source : pubmed.com)